I've never done any tests to see if it makes a difference or not, but when you bend wire into a right angle, it begins to act much more like an antenna (which is why traces on PCB's rarely have right angles, it's always two 135 degree bends, check it out some time). With this is mind, even though it looks way less neat and tidy, it's not necessarily a bad thing to have somewhat messy wiring, just as long as you keep your leads relatively short, and try not to cross any signal and power wires (except ground).