EMGs are low impedance pickups. So their resonance frequency is very high. All in all they provide a broad frequency spectrum, especially more highs than traditional pickups. This lays the base for shaping it in many ways.
What works quite well with my strat and classic pickups:
Using a state variable filter as resonant lowpass allows to make it sound more Tele, more P90, more PAF, more anything. Right, you don't get the true thing, but near.
With a little compression added the darker/humbuckerish sounds also feel (dynamically) a bit like humbuckers. You won't get the humbucking, of course.
Also works quite well to make split humbuckers more convincing.
To make it work with (full) humbuckers you first need to flat their natural resonance peak (with a para eq) and then apply the new higher peak to get it more like single coils. You won't really get the high sparkle and the dynamics, of course.
Edit: here's someone demoing it: