Is it RF interference or self oscillation (like a high pitch whine?). Self oscillation is common and you can do a few things to stop it. Try a small (100 ohm) resistor on the emitter of Q1 or a small capacitor (50-100pf) on Q2 from the collector to the base.
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Hi, Jakefuzz. Definitely RF, a really weird old music radio station, happens with a few of my other pedals as well.
Seems to vary depending on which of my strats I use. I have one with really low output Lollars and that gets the best reception

Both guitars are well shielded. I have read that using a small cap on the input might help. I'm using an AB switch at the front of my effects and that seems like a good place to experiment. Any other suggestions?
The Mangler sounds great BTW. Really happy with it.